Scientists say they have discovered why cats make your allergies crazy - and his research could also help people allergic to dogs.
An allergic reaction is actually the body's reaction to what he thinks is a bacteria or virus. The body mistakes the allergen (such as pollen or peanuts) as a substance that damages and defense riding a full-blown immune system need to remove it. This results in sneezing, wheezing, scratches and all sorts of unpleasant symptoms that we associate with allergies.
Cat Fel D1 protein - known as cat dander - has been known to cause serious allergic reactions. Since cat hair gets everywhere, is difficult to avoid. Before the study, the scientists do not know why it causes reactions in people.
They found that when Fel D1 is called with a toxin common bacterial lipopolysaccharide (LPS), a receptor that recognizes the pathogen called Toll-like receptor 4 (TLR4) activates contacted. TLR4 is the receptor that causes an allergic response to house dust mite and nickel metal. TLR4 when lit, it beefs up the body's immune response to Fel d1. The answer continues to grow, and the allergic symptoms of the person to be worse.
"What is cat dander an allergic reaction so strong in some people causes long been a mystery," lead author Dr Clare Bryant, Department of Veterinary Medicine, University of Cambridge, said in a statement released. "Not only have we learned that LPS exacerbates the response of the immune response to cat dander, identified the immune system recognizes the TLR4 receptor."
Researchers then human cells exposed to a drug that stops the reaction TLR4. Was able to block the cell reaction dander protein.
The researchers also found that another protein may F6 - dog dander that causes allergic reactions dogs - also reinforced by the presence of LPS. Together they activate TLR4.
"Since the drugs have been developed to inhibit the TLR4 receptor, we hope that our research into new and better treatments for allergic cat and dog may lead," Bryant said.
British Allergy Clinical Services Director Maureen Jenkins, told the BBC that this research was important to find allergies to cats and dogs in the people a way to get rid of - that would be the cat's meow.
"Cat allergen is particularly difficult to avoid, since it is a molecule" sticky "which takes place in all buildings in the shoes and clothing of the people," Jenkins said. "You can also still in a house that was on the walls and the ceiling or accessories, even held a few years after a cat living there. Therefore this new information, the identification of the receptor interaction specific immune system could pave the way for treatments for People with persistent disease caused by allergens pave cat and dog and in the future potentially house dust mite allergens. "
The study was published in the Journal of Immunology, 22, Published in July.
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